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Agenus Inc stimulontm qs 21
Stimulontm Qs 21, supplied by Agenus Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Article Title: Vaccination induces HIV broadly neutralizing antibody precursors in humans
Article Snippet: QS-21 was licensed by GSK from Antigenics LLC, a wholly owned subsidiary of Agenus Inc. (Delaware, USA).

Article Title: Target peptides for immunotherapy and diagnostics
Article Snippet: In some embodiments, the compositions comprise an adjuvant selected from the group consisting of montanide ISA-51 (Seppic, Inc., Fairfield, New Jersey, United States of America), QS-21 (Aquila Biopharmaceuticals, Inc., Lexington, Massachusetts, United States of America), tetanus helper peptides, GM-CSF, cyclophosamide, bacillus Calmette-Guerin (BCG), corynbacterium parvum, levamisole, azimezone, isoprinisone, dinitrochlorobenezene (DNCB), keyhole limpet hemocyanins (KLH), Freunds adjuvant (complete and incomplete), mineral gels, aluminum hydroxide (Alum), lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, dinitrophenol, diphtheria toxin (DT).

Article Title: Subunit vaccine for treatment or prevention of a respiratory tract infection
Article Snippet: 69(3): 194-202), neuroactive compound, especially human growth hormone (described in WO 01/24822), a chemokine (e.g., defensins 1 or 2, RANTES, MIP1-α, MIP-2, interleukin-8, or a cytokine (e.g., interleukin-1β, -2, -6, -10 or -12; interferon-γ; tumor necrosis factor-α; or granulocyte-monocyte-colony stimulating factor), muramyl dipeptide (MDP) variants, non-toxic variants of bacterial toxins, QS-21 (Antigenics Inc.), Quill A, N-acetylmuramyl-L-alanyl-D-isoglutamyl-L-alanine-2-[1,2-dipalmitoyl-s-glycero-3-(hydroxyphosphoryloxy)]ethylamide (MTP-PE) and others as described in Sarkar et al. 2019.

Article Title: Indoleamine 2,3-dioxygenase based immunotherapy
Article Snippet: QS-21 (Antigenics; Aquila Biopharmaceuticals, Framingham, MA) is a highly purified, water-soluble saponin that handles as an aqueous solution.

Article Title: Target peptides for immunotherapy and diagnostics
Article Snippet: The target peptide compositions may include one or more adjuvants such as for example: montanide ISA-51 (Seppic Inc., Fiarfield, New Jersey, United States of America); QS-21 (Aquila Biopharmaceuticals, Inc., Framingham, Nassachusetts, United States of America); Arlacel A; oeleic acid; tetanus helper peptides (such as but not limited to QYIKANSKFIGITEL (SEQ ID NO: 2376) and/or AQYIKANSKFIGITEL (SEQ ID NO: 2377); GM-CSF; cyclophosamide; bacillus Calmette-Guérin (BCG); Corynbacterium parvum; levamisole, azimezone; isoprinisone; dinitrochlorobenezene (DNCB); keyhole limpet hemocyanin (KLH); Freunds adjuvant (complete and incomplete); mineral gels; aluminum hydroxide (Alum); lysolecithin; pluronic polyols; polyanions; peptides; oil emulsions; nucleic acids (such as but not limited to soluble-stranded RNAs; dsRNA) dinitrophenol; diphtheria toxin (DT); toll-like receptor (TLR; such as but not limited to TLR3, TLR4, TLR7, TLR8, and/or TLR9) agonists (including but not limited to endotoxins such as lipopolysaccharide (LPS); monophosphoryl lipid A (MPL); and/or polyinosinic-polycytidylic acid (poly-ICLC/HILTONOL®; Oncovir, Inc., Washington, DC, United States of America); IMO-2055; glucopyranosyl lipid A (GLA); QS-21 (a saponin extracted from the bark of the Quillaja saponaria tree, also known as the soap bark tree or Soapbark); resiquimod (a TLR7/8 agonist); CDX-1401 (a fusion protein consisting of a fully human monoclonal antibody with specificity for the dendritic cell receptor DEC-205 linked to the NY-ESO-1 tumor antigen); Juvaris' Cationic Lipid-DNA Complex; Vaxfectin; and combinations thereof.

Article Title: Vaccination induces HIV broadly neutralizing antibody precursors in humans.
Article Snippet: David J. Leggat†, Kristen W. Cohen†, Jordan R. Willis†, William J. Fulp†, Allan C. deCamp†, Oleksandr Kalyuzhniy, Christopher A. Cottrell, Sergey Menis, Greg Finak, Lamar Ballweber-Fleming, Abhinaya Srikanth, Jason R. Plyler, Torben Schiffner, Alessia Liguori, Farhad Rahaman, Angela Lombardo, Vincent Philiponis, Rachael E. Whaley, Aaron Seese, Joshua Brand, Alexis M. Ruppel, Wesley Hoyland, Nicole L. Yates, LaTonya D. Williams, Kelli Greene, Hongmei Gao, Celia R. Mahoney, Martin M. Corcoran, Alberto Cagigi, Alison Taylor, David M. Brown, David R. Ambrozak, Troy Sincomb, Xiaozhen Hu, Ryan Tingle, Erik Georgeson, Saman Eskandarzadeh, Nushin Alavi, Danny Lu, Tina-Marie Mullen, Michael Kubitz, Bettina Groschel, Janine Maenza, Orpheus Kolokythas, Nadia Khati, Jeffrey Bethony, Shane Crotty, Mario Roederer, Gunilla B. Karlsson Hedestam, Georgia D. Tomaras, David Montefiori, David Diemert, Richard A. Koup, Dagna S. Laufer, M. Juliana McElrath*, Adrian B. McDermott*, William R. Schief*



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PCT applications related to M72/AS01 E vaccine candidate filed by GSK. Patent applications may focus on the adjuvant system (green)—or its individual components 3D-MPL (yellow) or QS-21 (blue)-, or on the tuberculosis vaccine (purple). Source: the authors, based on patent search and content analysis of the claims. Created in Biorender ( https://BioRender.com ).

Journal: Frontiers in Public Health

Article Title: TB vaccine development: monitoring international patent filings to anticipate access challenges

doi: 10.3389/fpubh.2025.1726153

Figure Lengend Snippet: PCT applications related to M72/AS01 E vaccine candidate filed by GSK. Patent applications may focus on the adjuvant system (green)—or its individual components 3D-MPL (yellow) or QS-21 (blue)-, or on the tuberculosis vaccine (purple). Source: the authors, based on patent search and content analysis of the claims. Created in Biorender ( https://BioRender.com ).

Article Snippet: The applicants and/or assignees of QS-21 PCT applications are: Cambridge Corporation, Aquila Pharmaceuticals, Antigenics, Q-VANT, Desert King, Croda International and Plant Bioscience.

Techniques: Adjuvant